A Funny Thing Happened on the Way to Mental Illness

David Granirer's comedy training for individuals with mental illness is proving to be a hit - a report from Canada's THE TYEE
Link

Alzheimer's and B3/Niacin

Vitamin B3/Niacin as Alzheimer's therapy:
"Memory loss is the signature feature of Alzheimer's disease, and therapies that prevent or delay its onset are urgently needed. Effective preventive strategies likely offer the greatest and most widespread benefits. Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance memory and synaptic plasticity. We evaluated the efficacy of nicotinamide, a competitive inhibitor of the sirtuins or class III NAD+-dependent HDACs in 3xTg-AD mice, and found that it restored cognitive deficits associated with pathology. Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increased acetylated -tubulin, a primary substrate of SirT2, and MAP2c, both of which are linked to increased microtubule stability. Reduced phosphoThr231-tau was related to a reduction of monoubiquitin-conjugated tau, suggesting that this posttranslationally modified form of tau may be rapidly degraded. Overexpression of a Thr231-phospho-mimic tau in vitro increased clearance and decreased accumulation of tau compared with wild-type tau. These preclinical findings suggest that oral nicotinamide may represent a safe treatment for AD and other tauopathies, and that phosphorylation of tau at Thr231 may regulate tau stability."
Link
More here: Link
A link has been established between Alzheimer's and calcium - a substance we take like candy in antacids. Link
What is the counterbalance for calcium? Magnesium. What makes magnesium work better? Niacin....

Mitochondrial Damage: Can it be repaired?

Yes.

Drugs designed to target one aspect of aging also seem to help repair DNA damage and regulate gene activity, preventing them from going haywire with the stresses of time.

"In principle, we now could have a way of reversing the effects of aging," said David Sinclair, a Harvard University gerontologist and co-founder of Sirtris Pharmaceuticals, a company best-known for its development of an experimental drug called resveratrol.
Resveratrol and similar compounds activate an enzyme called SIRT1. The enzyme rejuvenates mitochondria, the machines that power our cells. Mitochondrial breakdown has been associated with many age-related diseases, including heart disease, diabetes and dementia. Several labs in addition to Sirtris are researching compounds that target mitochondria.
The new findings suggest that SIRT1 fixes DNA in addition to mitochondria.

Sinclair's team found that unless SIRT1 enzymes gathered at sites where DNA had started to unravel, other DNA repair proteins failed to arrive. This allowed damage to progress, eventually causing dormant genes to come alive, a process called deregulation.
Some researchers think gene deregulation is a cause of aging: As cells get older, they produce less SIRT1, ostensibly becoming less able to repair faulty DNA and suppress the dormant genes.

But in mice either given resveratrol or genetically engineered to produce extra SIRT1 on their own, repairs went smoothly and quickly.
"One idea of why we age is that DNA becomes damaged or mutated," said Sinclair, lead author of the research published Wednesday in Cell. "But perhaps the main culprit is the effect of genes switching on and off, and that should be reversible."

Link


What to do? Detailed information for chronic fatigue patients but useful and informative for all to follow is in a pdf - here.
http://www.ijcem.com/files/IJCEM812001.pdf

Supplements of Alpha-lipoic acid, L-carnitine and Co-enzyme Q10 to restore mitrochondrial function http://articles.latimes.com/2008/aug/25/health/he-skeptic25

Scholarly articles on ALCAR treatment can be accessed at Mitochondrial.net, here.

One protocol in an individual with mitochondrial disease called for the following:
Alpha-lipoic Acid (ALA) 300 mg 2x/day
Co-Q-10 200 mg 2x/day
Creatine Monohydrate powder 2.5 gm 2x/day

Cancer Is A Fungus

You can stop cancer in its tracks simply by changing your body's pH. To do that, all you may need is a gentle, freely available ingredient: Baking soda or Bicarbonate soda. Isn't that wonderful?
Details here.
To learn more, please go to Dr. Simoncici's site.
Also see this article.
Listen to Dr. Simoncici on video here:

Hat tip and thanks for the suggestion to Mr. I.A.

"Ecstasy": The key to treating PTSD?

Caveat emptor!
Article here